Department of Neurosurgery

Chair
Professor Yasin Temel, MD, PhD

Principal Investigators
Linda Ackermans, MD, PhD
Govert Hoogland, PhD
Ali Jahanshahi, PhD
Mark Janssen, MD, PhD
Pieter Kubben, MD, PhD

Postdocs:
Christian Herff, PhD
Sarah-Anna Hescham, PhD
Stijn Michielse, PhD

Phd-students:
Mohammed Alahmari, MSc
Majed Aldehri, MD
Faris Almasabi, MD
Faisal Alosaimi, MD
Roman Assmann, MD
Jackson Boonstra, MSc
Jana Devos, MSc
Felix Gubler, MD
Jeroen Habets, MD
Margot Heijmans, MSc
Bethany Rose Isaacs, MSc
Huajie Liu, MD
Anne Mulders, MSc
Sylvana Pol, MSc
Marjolein Raijmakers, MSc
Milaine Roet, MD
Fred Schaper, MD
Longping Yao, MD
Yousef Yakkioui, MD
Gusta Zwieten, MD

PhD Alumni:
Pablo Andrade, MD, PhD
João Casaca Carreira, PhD
Roel Haeren, MD, PhD
Ruben Hendriksen, MD, PhD
Sarah Hescham, PhD
Ali Jahanshahi, PhD
Mark Janssen, MD, PhD
Paul Janssen, MD, PhD
Ersoy Kocabicak, MD, PhD
Melanie Lagiere, PhD
Evi Lemmens, PhD
Lee Wei Lim, PhD
Veronique Moers, MD, PhD
Birgit Plantinga, PhD
Kim Rijkers, MD, PhD
Olaf Schijns, MD, PhD
Lisa Schönfeld, PhD
Thibaut Sesia, PhD
Anouk Smeets, MD, PhD
Jasper Smit, MD, PhD
An Swijsen, PhD
Sonny Tan, MD, PhD
Dagmar Zeef, MD, PhD

Visiting scientist:
Mr. Onur Alptekin, Medtronic Inc, Istanbul, Turkey.
Dr. Ersoy Kocabicak, Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey.
Dr. Sonny Tan, Department of Neursurgery, Aachen University Hospital, Aachen, Germany.
Dr. Mehmet Tonge, Department of Neurosurgery, Medipol University, Istanbul, Turkey.
Prof.dr. Trevor Sharp, Department of Pharmacology, Oxford University, Oxford, United Kingdom.

Summary of the research
Our team has two research lines:

Basal ganglia: basal ganglia dysfuntion due to neurodegeneration leads often to major impairment in movement & behaviour. Prevalent basal ganglia disorders such as Parkinson's disease and Huntington's disease are therefore characterised by severe motor impairments like hypokinesia and chorea and debilitating behavioural abnormalities including depression and impulsivity. We are interested in developing novel therapies for these patients to treat both movement and behavioural symptoms. For this purpose, we use animal models of basal ganglia dysfunction and apply a variety of techniques including electrophysiology, behavioural assessments, neurochemistry, neuropharmacology and histology. Relevant findings can be used for clinical therapy development. In the clinical area, our research focuses on ultra-high structural, functional and chemical imaging and neurophysiological characterization of the human basal ganglia.

Skull base: we are interested in the etiology of skull base tumors, and in particular of chordoma. These are rare tumors with a poor prognosis. Using a developmental and molecular approach, our aim is to find molecular factors predicting disease course and treatment response, and directing novel therapy development. 

Selected Publications:

  • Aldehri M, Temel Y, Jahanshahi A, Hescham S. Fornix deep brain stimulation induces reduction of hippocampal synaptophysin levels. J Chem Neuroanat. 2019; 96:34-40.
  • Lozano A, Lipsman N, Bergman H, Brown P, Chabardes S, Chang J, Matthews K, McIntyre C, Schlaepfer T, Schulder M, Temel Y, Volkmann J and Krauss J. Deep brain stimulation: current challenges and future directions. Nature Reviews Neurology. 2019:1.
  • Aldehri M, Temel Y, Alnaami I, Jahanshahi A, Hescham S. Deep brain stimulation for Alzheimer's Disease: An update. Surg Neurol Int. 2018 Mar 7; 9:58. doi: 10.4103/sni.sni_342_17. eCollection 2018. Review.PMID: 29576909.
  • Forstmann BU, Isaacs BR, Temel Y. Ultra High Field MRI-Guided Deep Brain Stimulation. Trends Biotechnol. 2017;35(10):904-7.
  • Temel Y, Jahanshahi A. Treating brain disorders with neuromodulation. Science. 2015;347(6229):1418-9.
  • Smeets JS, Horstman AM, Schijns OE, Dings JT, Hoogland G, Gijsen AP, et al. Brain Plasticity: Measuring Protein Synthesis Rates in the Human Brain. The FASEB Journal. 2017;31(1 Supplement):164.2-.2.
  • Jansen JFA, Lemmens EMP, Strijkers GJ, Prompers JJ, Schijns OEMG, Kooi ME, Beuls EAM, Nicolay K, Backes WH, Hoogland G. Short and long term abnormalities after experimental febrile seizures. Neurobiol. Dis. 2008;32(2):293-301.  
  • Hendriksen RGF, Hoogland G, Schipper S, Hendriksen JGM, Vles JSH, Aalbers MW.  A possible role of dystrophin in neuronal excitability: a review of the current literature.  Neurosci. Biobehav. Rev. 2015;51:255-262.  
  • Hescham S, Temel Y, Schipper S, Lagiere M, Schönfeld L-M, Blokland A, Jahanshahi A. Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis. Brain Structure and Function. 2017;222(2):1069-75.
  • Jahanshahi A, Mirnajafi‐Zadeh J, Javan M, Mohammad‐Zadeh M, Rohani R. The antiepileptogenic effect of electrical stimulation at different low frequencies is accompanied with change in adenosine receptors gene expression in rats. Epilepsia. 2009;50(7):1768-79.


Funding agencies:
NWO (The Netherlands Organisation for Scientific Research)
ZonMW (The Netherlands Organisation for Health Research and Development)
Hersenstichting (Dutch Brain Foundation)
Chordoma Foundation
King Khalid University
Medtronic
Stichting St. Annadal
Chinese Scholarship Council
JPND EU
Imam Abdulrahman bin Faisal University
King Abdulaziz University