12th MHeNs Translational Neuroscience Workshop: Stress, depression and Alzheimer's Disease

January 23, 2018
Stayokay Maastricht, Maasboulevard 101, 6211 JW Maastricht

Major depression (MD) is a severe mental disorder characterized by alterations in mood and cognition, with disease severity correlating inversely with cognition scores. Neuropathology can be found abundantly in the limbic system, which is thought to regulate affect, attention and memory. Recently, it has been suggested that MD could serve as a risk factor for developing Alzheimer’s disease (AD), with patients suffering from lifetime depression having a twofold higher chance of developing AD and exhibiting more AD-related neuropathology. Modifications in e.g. the hypothalamo-pituitary-adranal (HPA) axis and the serotonergic system may contribute to the development of cognitive decline and eventually AD. These two systems may therefore be involved in the pathogenesis of both illnesses and could provide a link between MD and AD. This workshops takes a closer look at the link between stress, depression and Alzheimer’s disease, also highlighting alternative explanations on their association, e.g. by regarding MD as a prodromal phase or consequence of AD.